Experimental Treatment of SIV-Infected Macaques via Autograft of CCR5-Disrupted Hematopoietic Stem and Progenitor Cells.

Experimental Treatment of SIV-Infected Macaques via Autograft of CCR5-Disrupted Hematopoietic Stem and Progenitor Cells.
May 10, 2020 0 Comments

Hematopoietic stem cell (HSC)-based gene remedy concentrating on CCR5 represents a promising method to remedy human immunodeficiency virus kind 1 (HIV-1) an infection. Yet the preclinical animal mannequin with transplantation of autologous CCR5-ablated HSCs stays to be optimized. In this examine, 4 Chinese rhesus macaques of simian immunodeficiency virus (SIV) persistent an infection got long-term antiretroviral remedy (ART), throughout which …