Both adenine base editors (ABEs) and cytosine base editors (CBEs) have been lately revealed to induce transcriptome-wide RNA off-target modifying in a information RNA-independent method. Here we assemble a reporter system containing E.coli Hokb gene with a tRNA-like motif for strong detection of RNA modifying actions because the optimized ABE, ABEmax, induces extremely environment friendly A-to-I (inosine)… Continue reading