A DNA construction is described that may cleave single-stranded DNA oligonucleotides within the presence of ionic copper. This “deoxyribozyme” can self-cleave or can function as a bimolecular advanced that concurrently makes use of duplex and triplex interactions to bind and cleave separate DNA substrates. Bimolecular deoxyribozyme-mediated strand scission proceeds with kobs of 0.2 min-1, whereas the corresponding uncatalyzed response couldn’t be… Continue reading
