The JAK-STAT signal transmission is conserved evolutionarily in vertebrates and some other multicellular organisms. The combination of receptor-activated kinases and transcription factors make this signal cascade one of the central cellular regulatory pathways. In vertebrates, the JAK-STAT signal transmission is based on a network of protein kinases and transcription factors with which signals from different… Continue reading
Month: April 2020
DNA repair
DNA is the carrier of the genetic information that defines every living being. The genetic code defined in the DNA is an essential part of processes from the subcellular level to the appearance and function of the organism as a whole. Nevertheless, DNA is at risk from endogenous sources such as hydrolysis, oxidation, alkylation or… Continue reading